• Adiponectin Is Related to Cardiovascular Risk in Severe Mental Illness Independent of Antipsychotic Treatment 

      Reponen, Elina Johanna; Tesli, Martin Steen; Dieset, Ingrid; Steen, Nils Eiel; Vedal, Trude Seselie Jahr; Szabo, Attila; Werner, Maren Caroline Frogner; Lunding, Synve Hoffart; Johansen, Ingrid Torp; Rødevand, Linn; Andreassen, Ole Andreas; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-28)
      Background: Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) associated with elevated cardiovascular disease (CVD) risk, including obesity. Leptin and adiponectin are secreted by adipose tissue, with pro- and anti-inflammatory properties, respectively. The second generation antipsychotics (AP) olanzapine, clozapine, and quetiapine have been associated with high leptin ...
    • Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools 

      Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik K S; O'Connell, Kevin S; Frei, Oleksandr; Shadrin, Alexey; Cheng, Weiqiu; Bettella, Francesco; Rødevand, Linn; Ødegaard, Ketil Joachim; Fan, Chun C; Pirinen, Matti J; Hautakangas, Heidi M; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Tronvik, Erling Andreas; Kristoffersen, Espen Saxhaug; Zwart, John Anker Henrik; Nielsen, Jonas Bille; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Stovner, Lars Jacob; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir Lingaas; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-17)
      Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are implicated in both. A shared genetic basis to migraine and mental disorders has been suggested but previous studies have reported weak or non-significant genetic correlations and five ...
    • Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders 

      Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn; Hjell, Gabriela; Ormerod, Monica; Haram, Marit; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-19)
      Background: Low-grade inflammation may be part of the underlying mechanism of schizophrenia and bipolar disorder. We investigated if genetic susceptibility, infections or autoimmunity could explain the immune activation.<p> <p<Methods: Seven immune markers were selected based on indicated associations to severe mental disorders (IL1Ra, sIL-2R, IL-18, sgp130, sTNFR-1, APRIL, ICAM-1) and measured ...